MersV1, Main, Exploration, bibRecord, 000B41

Tissue Distribution of the MERS-Coronavirus Receptor in Bats

Identifieur interne : 000B41 ( Main/Exploration ); précédent : 000B40; suivant : 000B42

Tissue Distribution of the MERS-Coronavirus Receptor in Bats

Auteurs : W. Widagdo [Pays-Bas] ; Lineke Begeman [Pays-Bas] ; Debby Schipper [Pays-Bas] ; Peter R. Van Run [Pays-Bas] ; Andrew A. Cunningham [Royaume-Uni] ; Nils Kley [Allemagne] ; Chantal B. Reusken [Pays-Bas] ; Bart L. Haagmans [Pays-Bas] ; Judith M. A. Van Den Brand [Pays-Bas]

Source :

Scientific Reports [ 2045-2322 ] ; 2017.

RBID : PMC:5430768

Descripteurs français

KwdFr :
- Animaux, Cellules épithéliales (), Chiroptera, Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Muqueuse intestinale (), Muqueuse respiratoire (), Récepteurs viraux (analyse), Tropisme viral.
MESH :
- analyse : Récepteurs viraux.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- Animaux, Cellules épithéliales, Chiroptera, Muqueuse intestinale, Muqueuse respiratoire, Tropisme viral.

English descriptors

KwdEn :
- Animals, Chiroptera, Epithelial Cells (chemistry), Intestinal Mucosa (chemistry), Middle East Respiratory Syndrome Coronavirus (physiology), Receptors, Virus (analysis), Respiratory Mucosa (chemistry), Viral Tropism.
MESH :
- chemical , analysis : Receptors, Virus.
- chemistry : Epithelial Cells, Intestinal Mucosa, Respiratory Mucosa.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- Animals, Chiroptera, Viral Tropism.

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) has been shown to infect both humans and dromedary camels using dipeptidyl peptidase-4 (DPP4) as its receptor. The distribution of DPP4 in the respiratory tract tissues of humans and camels reflects MERS-CoV tropism. Apart from dromedary camels, insectivorous bats are suggested as another natural reservoir for MERS-like-CoVs. In order to gain insight on the tropism of these viruses in bats, we studied the DPP4 distribution in the respiratory and extra-respiratory tissues of two frugivorous bat species (Epomophorus gambianus and Rousettus aegyptiacus) and two insectivorous bat species (Pipistrellus pipistrellus and Eptesicus serotinus). In the frugivorous bats, DPP4 was present in epithelial cells of both the respiratory and the intestinal tract, similar to what has been reported for camels and humans. In the insectivorous bats, however, DPP4 expression in epithelial cells of the respiratory tract was almost absent. The preferential expression of DPP4 in the intestinal tract of insectivorous bats, suggests that transmission of MERS-like-CoVs mainly occurs via the fecal-oral route. Our results highlight differences in the distribution of DPP4 expression among MERS-CoV susceptible species, which might influence variability in virus tropism, pathogenesis and transmission route.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430768

DOI: 10.1038/s41598-017-01290-6
PubMed: 28446791
PubMed Central: 5430768

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p id="Par1">Middle East respiratory syndrome coronavirus (MERS-CoV) has been shown to infect both humans and dromedary camels using dipeptidyl peptidase-4 (DPP4) as its receptor. The distribution of DPP4 in the respiratory tract tissues of humans and camels reflects MERS-CoV tropism. Apart from dromedary camels, insectivorous bats are suggested as another natural reservoir for MERS-like-CoVs. In order to gain insight on the tropism of these viruses in bats, we studied the DPP4 distribution in the respiratory and extra-respiratory tissues of two frugivorous bat species (<italic>Epomophorus gambianus</italic>
 and <italic>Rousettus aegyptiacus</italic>
) and two insectivorous bat species (<italic>Pipistrellus pipistrellus</italic>
 and <italic>Eptesicus serotinus</italic>
). In the frugivorous bats, DPP4 was present in epithelial cells of both the respiratory and the intestinal tract, similar to what has been reported for camels and humans. In the insectivorous bats, however, DPP4 expression in epithelial cells of the respiratory tract was almost absent. The preferential expression of DPP4 in the intestinal tract of insectivorous bats, suggests that transmission of MERS-like-CoVs mainly occurs via the fecal-oral route. Our results highlight differences in the distribution of DPP4 expression among MERS-CoV susceptible species, which might influence variability in virus tropism, pathogenesis and transmission route.</p>
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   |wiki=    Sante
   |area=    MersV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:5430768
   |texte=   Tissue Distribution of the MERS-Coronavirus Receptor in Bats
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Serveur d'exploration MERS

Tissue Distribution of the MERS-Coronavirus Receptor in Bats

Tissue Distribution of the MERS-Coronavirus Receptor in Bats

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	Serveur d'exploration MERS
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